If you're wondering when to catch NFL football, let me break it down for you. The majority of NFL games typically take place on Sundays, with kickoff times usually slated for 1 p.m. and 4:25 p.m. EST. Additionally, you'll find a prime-time game on Sunday evenings at 8:20 p.m. EST. But don't forget about Monday Night Football, which starts at 8:15 p.m. EST, and the Thursday Night Football games, also at 8:20 p.m. EST. So, there's plenty of gridiron action to enjoy throughout the week!